Opened in 1975, Indy-South was the last standardized purpose-built Howard Johnson's Motor Lodge & Restaurant complex developed in Indiana. Constructed in the practical Mansard style for both the Lobby and Restaurant, the 150 room Motor Lodge was located on a five acre site. The property was unfortunately set some distance away from its nearby Interstate interchange and behind a truck stop and other roadside concerns rendering it with poor visibility. By 1988 the site ceased being a HoJo's, and eventually an Econo Lodge sign was tacked to the Lodge and remained as such until about 2006.

Not able to maintain even the minimal standards required by Choice Hotels lowliest brand, the once Orange Roofed site abandoned brandhood while briefly operating as The Indianapolis Inn South and then finally as the Best Inn Motel prior to its closure.